Il consumo di proteine nell’insufficienza renale cronica rivisitato

Home > In Depth Review

Pubblicato il 31 ottobre 2013

Dieta proteica e CKD

Protein diet and CKD

Il consumo di proteine nell'insufficienza renale cronica rivisitato

Protein intake in chronic renal failure revisited

Philippe Chauveau^1,2, Christian Combe^1,3, Michel Aparicio¹, Denis Fouque⁴

(1) Service de Néphrologie Transplantation Dialyse, Centre Hospitalier, Universitaire de Bordeaux, Bordeaux, France
(2) Aurad-Aquitaine, Gradignan, France
(3) Unité INSERM U1026 Biotis, Université Bordeaux Segalen, Bordeaux, France
(4) Service de Néphrologie-Dialyse-Nutrition, CARMEN-CENS, Centre Hospitalier Lyon Sud, Université de Lyon, France

Corrispondenza a: Philippe Chauveau; Aurad-Aquitaine, 2 allée des demoiselles; 33170, Gradignan, France; Tel: +33 557350242; Fax: +33 557350243; mail: Ph.chauveau@gmail.com

Introduction

Since the initial work by L.S Beale, over 140 years ago [1], restricted protein diet has been widely proposed to patients with chronic kidney disease (CKD) and numerous articles have been published on the benefits, risks and limits of this dietary prescription. The main conclusions which have been drawn from these studies are that efficacy of such diets on the progression of renal failure is at least questionable while effects are highly significant when onset of dialysis or death are the primary outcomes. Decrease in protein intake is associated with decrease in phosphate, sodium and acid load, CKD patients on such diets improve biochemical variables and clinical outcomes [2], [3], [4], [5], nevertheless, long-term nutritional safety remains questionable [6] (full text). Recently, the interest for protein intake in CKD has been renewed when it has been shown that a Western-style dietary pattern and its different components (high in saturated fat, sucrose and fructose, prot…

BibliografiaReferences

[1] Hensley M. Kidney function in health and disease In : Byham-Gray L.D., Burrows J.D., Chertow G.D. eds Nutrition in kidney diesase. Part 1 : Foundation for Clinical Practice and Overview. New York, NY : Human Press ; 2008 : 21-22

[2] Aparicio M, Chauveau P, Combe C et al. Low protein diets and outcome of renal patients. Journal of nephrology 2001 Nov-Dec;14(6):433-9

[3] Jibani MM, Bloodworth LL, Foden E et al. Predominantly vegetarian diet in patients with incipient and early clinical diabetic nephropathy: effects on albumin excretion rate and nutritional status. Diabetic medicine : a journal of the British Diabetic Association 1991 Dec;8(10):949-53

[4] Soroka N, Silverberg DS, Greemland M et al. Comparison of a vegetable-based (soya) and an animal-based low-protein diet in predialysis chronic renal failure patients. Nephron 1998;79(2):173-80

[5] Bergesio F, Monzani G, Guasparini A et al. Cardiovascular risk factors in severe chronic renal failure: the role of dietary treatment. Clinical nephrology 2005 Aug;64(2):103-12

[6] Mehrotra R, Nolph KD Treatment of advanced renal failure: low-protein diets or timely initiation of dialysis? Kidney international 2000 Oct;58(4):1381-8 (full text)

[7] Odermatt A The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease. American journal of physiology. Renal physiology 2011 Nov;301(5):F919-31 (full text)

[8] Filipowicz R, Beddhu S Optimal nutrition for predialysis chronic kidney disease. Advances in chronic kidney disease 2013 Mar;20(2):175-80

[9] Lacroix M, Gaudichon C, Martin A et al. A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats. American journal of physiology. Regulatory, integrative and comparative physiology 2004 Oct;287(4):R934-42

[10] Goraya N, Wesson DE Dietary management of chronic kidney disease: protein restriction and beyond. Current opinion in nephrology and hypertension 2012 Nov;21(6):635-40

[11] Friedman AN High-protein diets: potential effects on the kidney in renal health and disease. American journal of kidney diseases : the official journal of the National Kidney Foundation 2004 Dec;44(6):950-62

[12] Knight EL, Stampfer MJ, Hankinson SE et al. The impact of protein intake on renal function decline in women with normal renal function or mild renal insufficiency. Annals of internal medicine 2003 Mar 18;138(6):460-7

[13] D'Apolito M, Du X, Zong H et al. Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure. The Journal of clinical investigation 2010 Jan;120(1):203-13

[14] Bernstein AM, Treyzon L, Li Z et al. Are high-protein, vegetable-based diets safe for kidney function? A review of the literature. Journal of the American Dietetic Association 2007 Apr;107(4):644-50

[15] Combe C, Aparicio M Body building, high-protein diet, and progressive renal failure in chronic glomerulonephritis. Lancet 1993 Feb 6;341(8841):379-80

[16] KDIGO. Management of progression and complications of CKD Kidney Int Suppl. 2013 ;3 :73-90

[17] Moore LW, Byham-Gray LD, Scott Parrott J et al. The mean dietary protein intake at different stages of chronic kidney disease is higher than current guidelines. Kidney international 2013 Apr;83(4):724-32

[18] Aparicio M, Bellizzi V, Chauveau P et al. Do Ketoanalogues Still Have a Role in Delaying Dialysis Initiation in CKD Predialysis Patients? Seminars in dialysis 2013 Sep 9;

[19] Brenner BM, Lawler EV, Mackenzie HS et al. The hyperfiltration theory: a paradigm shift in nephrology. Kidney international 1996 Jun;49(6):1774-7

[20] Levey AS, Greene T, Sarnak MJ et al. Effect of dietary protein restriction on the progression of kidney disease: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation 2006 Dec;48(6):879-88

[21] Cianciaruso B, Pota A, Bellizzi V et al. Effect of a low- versus moderate-protein diet on progression of CKD: follow-up of a randomized controlled trial. American journal of kidney diseases : the official journal of the National Kidney Foundation 2009 Dec;54(6):1052-61

[22] Kasiske BL, Lakatua JD, Ma JZ et al. A meta-analysis of the effects of dietary protein restriction on the rate of decline in renal function. American journal of kidney diseases : the official journal of the National Kidney Foundation 1998 Jun;31(6):954-61

[23] Pedrini MT, Levey AS, Lau J et al. The effect of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: a meta-analysis. Annals of internal medicine 1996 Apr 1;124(7):627-32

[24] Fouque D, Wang P, Laville M et al. Low protein diets delay end-stage renal disease in non diabetic adults with chronic renal failure. The Cochrane database of systematic reviews 2000;(2):CD001892

[25] Brunori G, Viola BF, Parrinello G et al. Efficacy and safety of a very-low-protein diet when postponing dialysis in the elderly: a prospective randomized multicenter controlled study. American journal of kidney diseases : the official journal of the National Kidney Foundation 2007 May;49(5):569-80

[26] Kopple JD, Levey AS, Greene T et al. Effect of dietary protein restriction on nutritional status in the Modification of Diet in Renal Disease Study. Kidney international 1997 Sep;52(3):778-91

[27] Chauveau P, Couzi L, Vendrely B et al. Long-term outcome on renal replacement therapy in patients who previously received a keto acid-supplemented very-low-protein diet. The American journal of clinical nutrition 2009 Oct;90(4):969-74 (full text)

[28] Menon V, Kopple JD, Wang X et al. Effect of a very low-protein diet on outcomes: long-term follow-up of the Modification of Diet in Renal Disease (MDRD) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation 2009 Feb;53(2):208-17

[29] Ikizler TA Dietary protein restriction in CKD: the debate continues. American journal of kidney diseases : the official journal of the National Kidney Foundation 2009 Feb;53(2):189-91

[30] Phisitkul S, Hacker C, Simoni J et al. Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors. Kidney international 2008 Jan;73(2):192-9

[31] Kontessis PA, Bossinakou I, Sarika L et al. Renal, metabolic, and hormonal responses to proteins of different origin in normotensive, nonproteinuric type I diabetic patients. Diabetes care 1995 Sep;18(9):1233

[32] Lin CK, Lin DJ, Yen CH et al. Comparison of renal function and other health outcomes in vegetarians versus omnivores in Taiwan. Journal of health, population, and nutrition 2010 Oct;28(5):470-5

[33] Appel L.J., Moore T.J., Obarzanec E. et al. : A clinical trial of the effects of dietary patterns on blood pressure. DASH collaborative research group N Engl J Med 1997 ; 336 :1117-1124

[34] McNaughton SA, Bates CJ, Mishra GD et al. Diet quality is associated with all-cause mortality in adults aged 65 years and older. The Journal of nutrition 2012 Feb;142(2):320-5 (full text)

[35] Fraser GE Vegetarian diets: what do we know of their effects on common chronic diseases? The American journal of clinical nutrition 2009 May;89(5):1607S-1612S (full text)

[36] Appleby PN, Davey GK, Key TJ et al. Hypertension and blood pressure among meat eaters, fish eaters, vegetarians and vegans in EPIC-Oxford. Public health nutrition 2002 Oct;5(5):645-54

[37] Vang A, Singh PN, Lee JW et al. Meats, processed meats, obesity, weight gain and occurrence of diabetes among adults: findings from Adventist Health Studies. Annals of nutrition & metabolism 2008;52(2):96-104

[38] Krishnamurthy VM, Wei G, Baird BC et al. High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease. Kidney international 2012 Feb;81(3):300-6

[39] Teixeira SR, Tappenden KA, Carson L et al. Isolated soy protein consumption reduces urinary albumin excretion and improves the serum lipid profile in men with type 2 diabetes mellitus and nephropathy. The Journal of nutrition 2004 Aug;134(8):1874-80 (full text)

[40] Cupisti A, Ghiadoni L, D'Alessandro C et al. Soy protein diet improves endothelial dysfunction in renal transplant patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007 Jan;22(1):229-34 (full text)

[41] Hu FB Plant-based foods and prevention of cardiovascular disease: an overview. The American journal of clinical nutrition 2003 Sep;78(3 Suppl):544S-551S (full text)

[42] Jaradat MI, Molitoris BA Cardiovascular disease in patients with chronic kidney disease. Seminars in nephrology 2002 Nov;22(6):459-73

[43] Gutiérrez OM Sodium- and phosphorus-based food additives: persistent but surmountable hurdles in the management of nutrition in chronic kidney disease. Advances in chronic kidney disease 2013 Mar;20(2):150-6

[44] Moe SM, Zidehsarai MP, Chambers MA et al. Vegetarian compared with meat dietary protein source and phosphorus homeostasis in chronic kidney disease. Clinical journal of the American Society of Nephrology : CJASN 2011 Feb;6(2):257-64 (full text)

[45] Lafage MH, Combe C, Fournier A et al. Ketodiet, physiological calcium intake and native vitamin D improve renal osteodystrophy. Kidney international 1992 Nov;42(5):1217-25

[46] Scialla JJ, Appel LJ, Wolf M et al. Plant protein intake is associated with fibroblast growth factor 23 and serum bicarbonate levels in patients with chronic kidney disease: the Chronic Renal Insufficiency Cohort study. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2012 Jul;22(4):379-388.e1

[47] Di Iorio BR, Bellizzi V, Bellasi A et al. Phosphate attenuates the anti-proteinuric effect of very low-protein diet in CKD patients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013 Mar;28(3):632-40

[48] Shinohara K, Shoji T, Emoto M et al. Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease. Journal of the American Society of Nephrology : JASN 2002 Jul;13(7):1894-900 (full text)

[49] Siew ED, Ikizler TA Determinants of insulin resistance and its effects on protein metabolism in patients with advanced chronic kidney disease. Contributions to nephrology 2008;161:138-44

[50] Gin H, Aparicio M, Potaux L et al. Low-protein, low-phosphorus diet and tissue insulin sensitivity in insulin-dependent diabetic patients with chronic renal failure. Nephron 1991;57(4):411-5

[51] Rizzo NS, Sabaté J, Jaceldo-Siegl K et al. Vegetarian dietary patterns are associated with a lower risk of metabolic syndrome: the adventist health study 2. Diabetes care 2011 May;34(5):1225-7

[52] Kuo C.S., Loi N.S., Ho L.T., Lin C.L. : Insulin sensitivity in Chinese ovo-lacto-vegetarians compared with omnivores Eur J Clin Nutr 2004; 58: 312-316

[53] Dobre M, Yang W, Chen J et al. Association of Serum Bicarbonate With Risk of Renal and Cardiovascular Outcomes in CKD: A Report From the Chronic Renal Insufficiency Cohort (CRIC) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation 2013 Oct;62(4):670-8

[54] Kraut JA Effect of metabolic acidosis on progression of chronic kidney disease. American journal of physiology. Renal physiology 2011 Apr;300(4):F828-9 (full text)

[55] de Brito-Ashurst I, Varagunam M, Raftery MJ et al. Bicarbonate supplementation slows progression of CKD and improves nutritional status. Journal of the American Society of Nephrology : JASN 2009 Sep;20(9):2075-84 (full text)

[56] Goraya N, Simoni J, Jo C et al. Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. Kidney international 2012 Jan;81(1):86-93

[57] Kovesdy CP, Kopple JD, Kalantar-Zadeh K et al. Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy. The American journal of clinical nutrition 2013 Jun;97(6):1163-77

[58] Bellizzi V, Di Iorio BR, De Nicola L et al. Very low protein diet supplemented with ketoanalogs improves blood pressure control in chronic kidney disease. Kidney international 2007 Feb;71(3):245-51

Per visualizzare l'intero documento devi essere registrato e aver eseguito la login con utente e password.

Scarica l’APP del GIN per il tuo smartphone o tablet:

Versione PDF

 PDF

Per visualizzare l'intero documento devi essere registrato e aver eseguito la login con utente e password.

Contenuti articolo

release 1
pubblicata il 31 ottobre 2013
Da

Philippe Chauveau^1,2, Christian Combe^1,3, Michel Aparicio¹, Denis Fouque⁴

Corrispondenza a: Philippe Chauveau; Aurad-Aquitaine, 2 allée des demoiselles; 33170, Gradignan, France; Tel: +33 557350242; Fax: +33 557350243; mail: Ph.chauveau@gmail.com

Parole chiave: CKD, consumo di proteine, dieta vegetale

Key words: chronic kidney disease, plant-based diet, protein intake

Non ci sono commenti

Login